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Kidney Cancer treatment details. Biologic therapy. Royal Marsden Hospital, London, United Kingdom

Survival: 8.2 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Thalomid
Country: United Kingdom
City/State/Province: London
Hospital: Royal Marsden Hospital
Journal: Link
Date: 2/2006

Patients: This phase II study involved 60 patients with metastatic renal cell carcinoma (RCC).

Treatment: Patients were randomized to receive thalidomide (29 patients) or medroxyprogesterone (31 patients). Thalidomide is thought to inhibit angiogenesis (the growth of new blood vessels). In the thalidomide group, 10 patients were male and 10 were female and the median age was 59.

Toxicity: Grade 4 thromboembolism and grade 3 fatigue and paresthesia were reported.

Results: This study concluded that thalidomide is not a better therapeutic than medroxyprogesterone based on the results presented. The median survival in the thalidomide arm was 8.2 months.

Correspondence: Tim Eisen, PhD, FRCP

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