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Kidney Cancer treatment details. Biologic therapy. Immunotherapy. The Methodist Hospital Research Institute, Houston, Texas, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Immunotherapy
   
Drugs: Proleukin
Thalomid
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: The Methodist Hospital Research Institute
   
Journal: Link
   
Date: 2/2006

Description:
Patients: The phase I/II study involved a total of 52 patients with metastatic renal cell carcinoma.

Treatment: The treatment consisted of a combination of biological therapy (thalidomide) and immunotherapy (interleukin-2).

Toxicity: For phase I, toxicities included: grade 3/4 fluid retention and grade 3 constipation. For phase II, toxicities included: grade 4 fatigue and skin toxicities.

Results: Overall median survival was not reported. Survival for individual patients ranged from a low of 1 month (1 patient) to a high of over 45 months (1 patient).

Support: One of the authors has received a grant from Celegene Corporation. Celgene manufactures and/or markets thalidomide.

Correspondence: Robert J. Amato, D.O.

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