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Brain Cancer treatment details. Chemotherapy. Radiation. London Regional Cancer Centre , London, Ontario, Canada



Survival: 9.3 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs: Hycamtin
Country: Canada
   
City/State/Province: London, Ontario
   
Hospital: London Regional Cancer Centre
   
Journal: Link
   
Date: 7/2002

Description:
Patients: This Phase II trial included 87 patients with glioblastoma multiforme. (84 patients were considered assessable.)

Treatment: Treatment consisted of standard cranial radiation therapy plus the chemotherapy drug topotecan (hycamtin).

Toxicity: Toxicities included: neutropenia (there were 44 grade 4 neutropenias), leucopenia, thrombocytopenia (grades 1-4), nausea, vomiting (grades 1-3), hearing loss (grades 1-3), skin toxicity (grades 1-3), pulmonary (grades 1-3), hepatic (grades 1-2), neurologic, and fever.

Results: The median survival for all patients was 9.3 months.

Correspondence: Barbara Fisher, MD

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