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Colon Cancer treatment details. Chemotherapy. University General Hospital of Heraklion, Heraklion, Greece



Survival: 21.5 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Camptosar
Eloxatin
Country: Greece
   
City/State/Province: Heraklion
   
Hospital: University General Hospital of Heraklion
   
Journal: Link
   
Date: 2/2006

Description:
Patients: This Phase III study involved 285 patients with metastatic colorectal cancer. The patients were randomly divided into two groups. Group B had 137 patients (76 men, 61 women) with a median age of 66 years. Metastatic sites included liver and lung, and 60% of patients in both arms had two or more metastatic sites.

Treatment: Group B received the FOLFOXIRI treatment protocol, consisting of the following four chemotherapeutic agents: oxaliplatin, irinotecan, 5-fluorouracil, and leucovorin.

Toxicity: For Group B, two patients died of febrile neutropenia during treatment. Other grade 3-4 toxicities included neutropenia, alopecia, diarrhea, nausea/vomiting, fatigue, mucositis, neurological disorders, and nausea/vomiting.

Results: The median overall survival was 19.5 months for Group A and 21.5 months for Group B; this difference was not statistically significant. Group A had 5 complete response, 44 partial responses, and 39 with stable disease. Group B had 9 complete response, 50 partial responses and 43 with stable disease. The authors concluded, "the present study failed to demonstrate any survival advantage of the FOLFOXIRI over the FOLFIRI regimen."

Correspondence: Dr. J. Souglakos

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