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Brain Cancer treatment details. Chemotherapy. Institut Gustave-Roussy, Villejuif, France

Survival: N/R
Toxicity Grade: 4
Treatments: Chemotherapy
Country: France
City/State/Province: Villejuif
Hospital: Institut Gustave-Roussy
Journal: Link
Date: 7/2002

Patients: Seventeen patients with recurrent glioblastoma multiforme were enrolled in this Phase II study.

Treatment: Treatment consisted of 9-Nitro-camptothecin (RFS2000), a new oral topoisomerase I inhibitor (a type of chemotherapy).

Toxicity: Grade 3-4 toxicity was reported in 5 patients. Febrile neutropenia that required hospitalization occurred for 3 patients. Other toxicities included: diarrhea, fatigue, nausea and vomiting, arthralgia and myalgia, stomatitis, urinary infection.

Results: Among the 15 eligible patients, no objective responses were observed. The median time to progression (return/regrowth of the tumor) was 44 days. Median survival was not presented.

Correspondence: E. Raymond, MD

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