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Rectal Cancer treatment details. Chemotherapy. Radiation. Duke University Medical Center, Durham, North Carolina, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs: Xeloda
Country: United States
   
City/State/Province: Durham, North Carolina
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 2/2006

Description:
Patients: This Phase I study involved 6 patients (4 men, 2 women, median age 71) with rectal cancer and 10 patients (6 men, 4 women, median age 65) with pancreatic cancer.

Treatment: Treatment consisted of radiotherapy and two drugs: gefitinib (a biological agent) and capecitabine (chemotherapy).

Toxicity: Grade 3-4 toxicities included diarrhea, nausea/vomiting, dehydration, and anorexia.

Results: The median overall survival was not reported. The authors concluded, "The combination of gefitinib, capecitabine, and radiation in pancreatic and rectal cancer patients resulted in significant toxicity."

Support: Several authors disclosed prior relationships as consultants, honoraria recipients, and grant recipients related to Roche or AstraZeneca. Roche manufactures and/or markets capecitabine. AstraZeneca manufactures and/or markets gefitinib.

Correspondence: Brian G. Czito

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