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Colon Cancer treatment details. Chemotherapy. University of Pittsburgh School of Medicine, Pittsburgh, PA, United States



Survival: 10.1 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Pittsburgh, PA
   
Hospital: University of Pittsburgh School of Medicine
   
Journal: Link
   
Date: 3/2006

Description:
Patients: This Phase II study involved 14 patients (11 men, 3 women, median age 70) with advanced colorectal cancer. All patients had received surgery or chemotherapy before the study.

Treatment: Treatment consisted of one chemotherapeutic agent: rubitecan.

Toxicity: Grade 3-4 toxicities included anemia, diarrhea and elevated bilirubin.

Results: The median overall survival was 10.1 months, and no objective responses were observed. The authors concluded, "Administration of rubitecan was well-tolerated, but this schedule does not appear to have clinical activity in patients with advanced previously treated colorectal cancer."

Correspondence: Ramesh K. Ramanathan

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