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Kidney Cancer treatment details. Immunotherapy. Hoag Cancer Hospital, Newport Beach, CA, United States

Survival: 15.0 months
Toxicity Grade: 4
Treatments: Immunotherapy
Country: United States
City/State/Province: Newport Beach, CA
Hospital: Hoag Cancer Hospital
Journal: Link
Date: 4/2006

Patients: This Phase II trial involved 36 patients with metastatic renal cell carcinoma. There were 25 men and 11 women and the median age was 57. Prior treatment included nephrectomy (31), radiation (8), biotherapy (7), and chemotherapy (4). Sites of disease included 26 lung, 13 lymph node, 9 bone, 8 liver, 4 kidney, and 4 adrenal locations.

Treatment: The treatment consisted of a type of immunotherapy subcutaneous interferon-alpha2b (IFN), followed by a schedule of bolus and continuous interleukin-2 (IL- 2).

Toxicity: One patient died 1.6 months of starting therapy. This patient had rapidly progressive disease and also developed renal insufficiency that required dialysis. Grade 4 toxicities included renal (creatinine), liver (bilirubin, SGOT and other liver enzymes), cardiovascular (hypotension), rash, and myalgia.

Results: The median overall survival was 15.0 months.

Correspondence: Robert O. Dillman, MD

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