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Lung Cancer treatment details. Chemotherapy. Radiation. Centre Hospitalier Lyon Sud, Pierre-Benite, France



Survival: 5.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs: Platinol
Temodar
Country: France
   
City/State/Province: Pierre-Benite
   
Hospital: Centre Hospitalier Lyon Sud
   
Journal: Link
   
Date: 6/2006

Description:
Patients: This Phase II trial involved a total of 50 patients with advanced non-small-cell lung cancer with brain metastases. There were 40 men and 10 women. Subtypes included squamous cell (30 patients), adenocarcinoma (10 patients), and large cell (10 patients).

Treatment: The treatment consisted of chemotherapy (temozolomide and cisplatin) followed by whole brain radiotherapy.

Toxicity: One patient died before the second cycle of chemotherapy because of pulmonary embolism. Grade 4 toxicities included netropenia and thrombocytopenia.

Results: The median overall survival was 5 months.

Support: The study was supported by Schering-Plough, Paris, France.

Correspondence: Dr. P. J. Souquet

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