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Kidney Cancer treatment details. Gene Therapy. London Health Sciences Centre, Ontario, Canada



Survival: N/R
   
Toxicity Grade: 4
   
Treatments: Gene Therapy
   
Drugs:
Country: Canada
   
City/State/Province: Ontario
   
Hospital: London Health Sciences Centre
   
Journal: Link
   
Date: 3/2006

Description:
Patients: This Phase II trial involved a total of 17 patients with metastatic renal cell carcinoma. There were 11 men and 6 women. The median age was 60.

Treatment: The treatment consisted of a type of gene therapy antisense oligonucleotide MG98 to try to inhibit DNA methyltransferase 1.

Toxicity: Grade 3 or 4 toxicities included elevations in hepatic transaminases.

Results: There were no objective responses.

Support: The study was supported in part by MethylGene, Inc.

Correspondence: Eric Winquist, MD

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