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Brain Cancer treatment details. Chemotherapy. Azienda Ospedale-Universita, Padova, Italy



Survival: 13.8 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: BCNU, BiCNU
Matulane
Oncovin
Country: Italy
   
City/State/Province: Padova
   
Hospital: Azienda Ospedale-Universita
   
Journal: Link
   
Date: 6/2002

Description:
Patients: This Phase II study involved 58 patients with glioblastoma multiforme. These patients had already relapsed or progressed after surgery and standard radiotherapy.

Treatment: The treatment consisted of the administration of three chemotherapy drugs, procarbazine (matulane), BCNU, and vincristine (oncovin).

Toxicity: Five patients developed partially reversible grade 3 pulmonary toxic effects. Two patients had pulmonary embolism. One patient developed lower limb deep vein thrombosis. Other toxicities included grade 1-4 neutropenia and thrombocytopenia, grade 1-3 anemia, grade 1-3 nausea and vomiting, grade 1-3 hepatic toxic effect, and grade 3 cutaneous allergy.

Results: Median survival time from start of chemotherapy was 13.8 months.

Correspondence: Alba A. Brandes, MD

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