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Breast Cancer treatment details. Biologic therapy. Chemotherapy. Vancouver Cancer Centre, Vancouver, B.C., Canada

Survival: ?
Toxicity Grade: 3
Treatments: Biologic therapy
Drugs: Herceptin
Country: Canada
City/State/Province: Vancouver, B.C.
Hospital: Vancouver Cancer Centre
Journal: Link
Date: 5/2006

Patients: This Phase II trial involved a total of 30 women with HER-2 overexpressing metastatic breast cancer.

Treatment: The treatment consisted of chemotherapy (pegylated liposomal doxorubicin) and biological therapy trastuzumab (herceptin) a type of monoclonal antibody.

Toxicity: Grade 3-4 toxicities included mucositis, hand-foot syndrome, and neutropenia.

Results: The authors report that at a median follow-up of 13.9 months, the median progression-free survival was 12.0 months and the median overall survival has not yet been reached.

Support: One author was an employee of Schering Canada. Another was a consultant with Schering Plough and had received honoraria from Schering Plough and Hoffman la Roche. Three more authors received honoraria from Roche, Hoffman LaRoche and Genetech, and Schering Canada.

Correspondence: Stephen Chia, MD

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