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Breast Cancer treatment details. Chemotherapy. The Netherlands Cancer Institute, Amsterdam, Netherlands

Survival: 16.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Taxol
Country: Netherlands
City/State/Province: Amsterdam
Hospital: The Netherlands Cancer Institute
Journal: Link
Date: 9/2006

Patients: 23 patients were treated in this study, the median age was 48 years old, ranging from 34-65. All had histologically confirmed advanced breast cancer, a maximum of two prior chemotherapy regimens, and no taxane therapy. 62% had oestrogen and/or progesterone positive tumour and 90% had more than one metastatic site.

Treatment: This phase II study combined oral paclitaxel, a chemotherapy, with ciclosporin, an immunosupressant drug that (according to the authors) increases the bioavailability of paclitaxel.

Toxicity: Grade 3-4 neutropenia was experienced by 15 ( 54%) of the patients, including 3 with fever. Gastrointestinal toxicities were most common; grade 1 and 2 nausea and vomiting were reported in 90 and 75% of patients, and 71% reported diarrhea.

Results: This phase II study in women with metastatic breast cancer revealed an overall median survival of 16 months.

Support: This study was supported in part by IVAX Research, Inc, Miami, USA. One author is employed by IVAX Research Incorporated, which makes paclitaxel

Correspondence: Dr. HH Helgason

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