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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Leicester Royal Infirmary, Leicester , United Kingdom

Survival: ?
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Adrucil
Country: United Kingdom
City/State/Province: Leicester
Hospital: Leicester Royal Infirmary
Journal: Link
Date: 4/2007

Patients: This phase IB study involved thirty-five patients with advanced colorectal cancer, 18 of which were men, 17 were women. The median age was 63 years. Twelve of the patients had prior chemotherapy

Treatment: All patients received FOLFOX4 ( chemotherapy - oxaliplatin/5-fluorouracil (5-FU) and folinic acid - leucovorin) and the oral angiogenesis inhibitor - PTK787/ZK.

Toxicity: Grade 4 vomiting, dizziness, ataxia, and neutropenia toxicities were reported. The most common toxicities were nausea, diarrhea, fatigue/lethargy, and vomiting.

Results: The estimated median progression free survival was 11.4 months.

Support: This study was supported by Novartis Pharmaceuticals and Schering, which partnered to develop and market PTK787.

Correspondence: Dr. A. L. Thomas

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