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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Hopital Tenon, Paris, France

Survival: 15.8 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Adrucil
Country: France
City/State/Province: Paris
Hospital: Hopital Tenon
Journal: Link
Date: 1/2007

Patients: This phase II study involved 42 patients with metastatic colorectal cancer. Twenty-four were men and 18 were women, and the median age was 60, ranging from 31-76. 67% had stage IV disease.

Treatment: All 42 patients received celecoxib (a non-steroidal anti-inflammatory drug) and the chemotherapy drugs 5FU (Fluorouracil) and oxaliplatin, and folinic acid.

Toxicity: There were two episodes of grade 4 toxicity; vomiting and thrombocytopenia. Grade 3 toxicities reported were nausea, diarrhea, peripheral neuropathy, neutropenia and thrombocytopenia.

Results: Median overall survival was 15.8 months. Thirty-five patients stopped the study for progression, toxicity, personal choice, or the investigator’s decision

Support: This study was supported by a grant from Pfizer. Pfizer makes celecoxib and markets it as Celebrex®

Correspondence: Dr. T. Andre

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