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Brain Cancer treatment details. Chemotherapy. Department of Medical Oncology and Beatson Oncology Centre, Glasgow, United Kingdom



Survival: N/R
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: Glasgow
   
Hospital: Department of Medical Oncology and Beatson Oncology Centre
   
Journal: Link
   
Date: 5/2002

Description:
Patients: This Phase II study involved 16 patients with recurrent glioblastoma multiforme. (One ineligible patient was excluded from efficacy evaluation.)

Treatment: Treatment consisted of the administration of XR5000. (XR5000, a tricyclic carboxamide, is a chemotherapeutic agent that intercalates DNA and inhibits both topoisomerase I and II.)

Toxicity: Toxicities included: chest pain (grade 3), constipation (grade 3), neutropenia (grade 3), fever (grade 4), shivers (grade 3), axillary thrombosis (grade 3), and “cancer pain” (grade 3).

Results: There were no objective responses.

Support: Xenova sponsored this study. Xenova markets XR5000.

Correspondence: Dr. C. Twelves

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