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Kidney Cancer treatment details. Chemotherapy. University of Chicago, Chicago, Illinois, United States

Survival: 14.5 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Gemzar
Country: United States
City/State/Province: Chicago, Illinois
Hospital: University of Chicago
Journal: Link
Date: 9/2006

Patients: This phase II study involved 60 patients with metastatic kidney cancer, four of which did not did not start the treatment. Forty-three were men and 13 were women, with ages ranging from 54 to 69 years. Seventy-nine percent had a prior nephrectomy and 75% had a prior systemic therapy (either chemotherapy or biologic).

Treatment: 56 patients received the chemotherapy drugs gemcitabine and capecitabine.

Toxicity: Grade 3 or 4 neutropenia occurred in 45% of patients, one with fever. Other grade 3 toxicities included cardiac ischemia, thrombosis, and a gastrointestinal bleed. One patient had an acute abdomen requiring bowel resection who subsequently died from a hemorrahagic cardiovascular event while receiving warfarin.

Results: The median survival time was 14.5 months. There were no complete responses, and the median time to disease progression was 5.6 months.

Correspondence: Walter M. Stadler, M.D.

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