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Melanoma treatment details. Biologic therapy. Burmingham Comprehensive Cancer Center, Bimingham, Alabama, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Bimingham, Alabama
   
Hospital: Burmingham Comprehensive Cancer Center
   
Journal: Link
   
Date: 12/2007

Description:
Patients: This Phase I study involved 17 patients with stage IV melanoma with metastatic lesions. The age range was 36-85 years.

Treatment: Patients were given the investigational agent KW-2871, a monoclonal antibody.

Toxicity: One patient had grade 4 seizures, grade 3 urticaria, and grade 2 fever/chills/rigor. This patient had a history of brain metasteses. Other grade 3 toxicities included laryngeal edema, chest tightness, and urticaria. All patients experienced at least one toxic event.

Results: Survival was not reported because the effectiveness of this treatment was not an aim of the trial, it was to determine doses and toxicities.

Support: This work was supported by Kyowa Pharmaceuticals, which employees one of the authors and developed KW-2871.

Correspondence: Dr. Andres Forero

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