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Ovarian Cancer treatment details. Chemotherapy. Charite Virchow University Hospital, Berlin, Germany

Survival: 45.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Paraplatin
Country: Germany
City/State/Province: Berlin
Hospital: Charite Virchow University Hospital
Journal: Link
Date: 4/2007

Patients: This phase II study involved 129 women with epithelial ovarian cancer of FIGO stages II B to IV. The mean age was 59 years, and all had previously undergone surgical treatment.

Treatment: Patients were infused with the two chemotherapy drugs paclitael and carboplatin.

Toxicity: Grade 4 toxicities in these women: 13 had anaemia, 16 had leucopenia, 2 had thrombopenia, and 1 had constipation. The most common grade 3 toxicities were alopecia (occurring in 74.4% of the patients), and anaemia (in 45.7% of patients). Grade 1 and 2 toxicities included alopecia, neuropathy, anorexia, diarrhea, nausea, leukopenia, dyspnea, skin changes, pain and infection.

Results: Forty-three patients ended treatment early because of toxic events. The median overall survival was 45 months. Median progression free survival was 22 months.

Correspondence: Dr. Jalid Sehouli

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