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Ovarian Cancer treatment details. Biologic therapy. National Cancer Institute, Bethesda, Maryland, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Bethesda, Maryland
   
Hospital: National Cancer Institute
   
Journal: Link
   
Date: 4/2007

Description:
Patients: This phase II study involved 24 women with recurrent epithelial ovarian cancer with a median age of 53, ranging from 33-67. Of these, 16 completed the treatment and were evaluated by the researchers.

Treatment: These women were treated with gefitinib (Iressa), a small molecule that inhibits the epidermal growth factor receptor.

Toxicity: Grade 4 toxicities were experienced by two women: one had hyponatremia and another hemorrhaged due to her spleen rupturing. Grade 3 toxicities were abdominal pain, diarrhea, and an abnormal lab result. Grade 2 toxicities included anorexia, diarrhea, nausea, vomiting, fatigue, weight loss, and skin changes.

Results: There were no complete or partial responses. Nine patients had stable disease for more than two months. Median survival times were not reported.

Correspondence: Elise C. Kohn, M.D.

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