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Ovarian Cancer treatment details. Chemotherapy. Hôpital Hôtel-Dieu, Paris, France



Survival: 32.0 months
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
   
Drugs: Doxil
Paraplatin
Country: France
   
City/State/Province: Paris
   
Hospital: Hôpital Hôtel-Dieu
   
Journal: Link
   
Date: 11/2006

Description:
Patients: This phase II trial involved 104 women with advanced ovarian cancer that had relapsed. All patients had been pretreated with platinum and taxane. The median age was 61, ranging from 23-79.

Treatment: Treatment consisted of two chemotherapeutic agents: pegylated liposomal doxorubicin (Doxil®, CAELYX®) and carboplatin.

Toxicity: Grade 3 toxicities included nausea/vomiting, mucositis, infection, neuropathy, asthenia, and hypersensitivity. Grade 3 toxicities were observed in 1-7% of the patients. More common were grade I and II toxicities, including alopecia, nausea/vomiting, mucositis, neuropathy, and asthenia.

Results: The median overall survival time was 32 months. The median progression-free survival was 9.4 months.

Support: This study was supported by a grant from Schering-Plough, France. Schering-Plough markets pegylated liposomal doxorubicin under the trade name CAELYX®.

Correspondence: Dr. E Pujade-Lauraine

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