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Brain Cancer treatment details. Chemotherapy. Radiation. University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States



Survival: 10.5 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs: Temodar
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: University of Texas M.D. Anderson Cancer Center
   
Journal: Link
   
Date: 3/2002

Description:
Patients: This Phase II study involved 44 patients with recurrent glioblastoma multiforme.

Treatment: The treatment consisted of temozolomide (temodar) and the matrix metalloproteinase inhibitor marimastat (MRM) after radiation therapy.

Toxicity: The most notable toxicity was arthropathy. Joint complaints were reported in 21 patients (47%) and were grade 3 or 4 in 17 patients (38%). Other grade 3-4 toxicities included: vomiting, fatigue/lethargy, thrombocytopenia, seizure, hyperglycemia, and thrombosis.

Results: Median overall survival (measured from the first day of treatment) was 45 weeks (10.5 months).

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