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Brain Cancer treatment details. Biologic therapy. Radiation. Surgery. M.D. Anderson Cancer Center, Houston, Texas, United States



Survival: 10.7 months
   
Toxicity Grade:
   
Treatments: Biologic therapy
Radiation
Surgery
   
Drugs:
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: M.D. Anderson Cancer Center
   
Journal: Link
   
Date: 7/2006

Description:
Patients: This study involved 162 patients with intracranial glioblastoma multiforme or gliosarcomas. They were from 20 different cancer treatment centers. Fifty-four of the patients were women and 108 were men.

Treatment: Seventy-nine people received a placebo, and 83 received the biological therapy - marimastat. Marimastat is an inhibitor of the matrix metalloproteases family of enzymes. All patients had previously been treated with surgery and radiotherapy.

Toxicity: Musculoskeletal toxicity including aches, pains (sometimes restricting movement), and inflammation was the only reported toxicity.

Results: The median survival time was 37.9 weeks for the group receiving placebo and 42.9 weeks for those receiving marimastat.

Support: The authors state that none of them ‘currently have a financial interest in marimastat’. One author is employed by Origin Pharmaceuticals Ltd.

Correspondence: Dr. Victor A. Levin

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