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Mesothelioma Cancer treatment details. Chemotherapy. Surgery. University Hospital Zurich, Zurich, Switzerland

Survival: 23.0 months
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Gemzar
Country: Switzerland
City/State/Province: Zurich
Hospital: University Hospital Zurich
Journal: Link
Date: 4/2007

Patients: This study enrolled 61 patients (57 men and 4 women) with malignant pleural mesothelioma. The median age was 59 years, ranging from 44-72.

Treatment: Fifty-eight patients completed three cycles of chemotherapy with cisplatin and gemcitabine. 45 of these patients had surgery (extrapleural pneumonectomy) and radiation after finishing the chemotherapy.

Toxicity: Grade 3 and 4 toxicities included: nausea and vomiting, myalgia, dyspnea, leucopenia, and thrombocytopenia. Major postoperative complications occurred in 16 (35%)
of the patients undergoing EPP. Mortality was 2.2%

Results: The median overall survival was 19.8 months for the 61 patients. For the 45 that also underwent surgery, the median overall survival was 23 months.

Correspondence: Dr. R.A. Stahel

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