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Brain Cancer treatment details. Chemotherapy. Dana-Farber Cancer Institute, Boston, MA, United States



Survival: 9.5 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Dana-Farber Cancer Institute
   
Journal: Link
   
Date: 4/2007

Description:
Patients: This phase II trial involved twenty-six patients with metastatic melanoma. There were 12 men and 14 women. The median age was 45 years, ranging from 28-70. The patientsí disease had progressed during or after they were treated with biochemotherapy: cisplatin, vinblastine, dacarbazine, interleukin-2 and interferon alfa-2b.

Treatment: Patients were treated with an infusion of high-dose bolus interleukin-2.

Toxicity: Grade 3 and 4 toxicities included anemia, leukopenia, thrombocytopenia, tachycardia, hypotension, nausea, vomiting, diarrhea, renal and hepatic abnormalities (oliguria and increased bilirubin), infection, rash, and fatique/delirium. Each of these occurred in less than 10 patients, except for hepatic (liver) abnormality, which occurred in 13 patients.

Results: The median overall survival was 9.6 months (41.9 weeks). The median progression-free survival was 10 weeks.

Correspondence: Dr. Sanjiv S. Agarwala

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