Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results

Click here to go back to your search results.

Brain Cancer treatment details. Chemotherapy. Radiation. Institut Claudius Regaud, Toulouse, France

Survival: 12.0 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: France
City/State/Province: Toulouse
Hospital: Institut Claudius Regaud
Journal: Link
Date: 8/2007

Patients: This phase I study involved 13 patients with newly diagnosed glioblastoma multiforme that had not received any treatment except for biopsy or surgery. There were 8 men and 5 women; the median age was 55 years, ranging from 28 to 74.

Treatment: Patients were given radiation treatment and the chemotherapy drug Tipifarnib. This drug is thought to make cancer cells more sensitive to radiation therapy.

Toxicity: One patient died suddenly during the study. Another patient developed acute pneumonitis, grade 4 neutropenia, grade 2 thrombocytopenia, and grade 3 phlebitits (vein inflammation) and died thirty days later. Other toxicities included arthralgia, constipation, dysgeusia (a distorted sense of taste), nausea, rash, and stomatitis.

Results: The median overall survival was 12 months, ranging from 5.2-21.

Support: This research study was supported by Johnson & Johnson Pharmaceutical Research and Development. The drug Tipifarnib was developed by and provided for the study by Johnson & Johnson.

Correspondence: Dr. Elizabeth Cohen-Jonathan Moyal

E-mail to a Friend Email Physician More Information