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Brain Cancer treatment details. Radiation. Research Center for Charged Particle Therapy, Chiba-City , Japan



Survival: 35.0 months
   
Toxicity Grade: 2
   
Treatments: Radiation
   
Drugs:
Country: Japan
   
City/State/Province: Chiba-City
   
Hospital: Research Center for Charged Particle Therapy
   
Journal: Link
   
Date: 10/2007

Description:
Patients: This phase I/II trial involved 48 patients with malignant gliomas. Sixteen patients had anaplastic astrocytoma and 32 had glioblastoma multiforme. The median age was 53 years, ranging from 18 to 78. The majority (60%) were men.

Treatment: Patients were treated with x ray radiotherapy, then chemotherapy (specific drugs were not identified), then carbon-ion radiotherapy.

Toxicity: Acute grade 4 and grade 3 white blood cell and platelet toxicities were reported. Toxicities that occurred later included grade 1 and 2 skin and brain changes.

Results: The median overall survival was 35 months for patients with anaplastic astrocytoma and 17 months for those with glioblastoma multiforme. Increased survival time was associated with increased doses of radiation.

Correspondence: Jun-etsu Mizoe

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