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Colon Cancer treatment details. Biologic therapy. Chemotherapy. University General Hospital of Heraklion, Heraklion, Crete, Greece

Survival: 10.7 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Greece
City/State/Province: Heraklion, Crete
Hospital: University General Hospital of Heraklion
Journal: Link
Date: 11/2006

Patients: This phase II study involved 40 patients with metastatic colorectal cancer. There were 23 men and 17 women. The median age was 65, ranging from 35-84 years. All had previously been treated with a oxaliplatin-based chemotherapy but progressed.

Treatment: Patients were treated with the chemotherapy drugs oxaliplatin and capecitabine and the biological therapy cetuximab. Cetuximab is an antibody that binds to a molecule called the epidermal growth factor receptor.

Toxicity: One instance of grade 4 diarrhea was reported. Grade 3 adverse events included neutropenia, nausea/vomiting, diarrhea, neurotoxicity, fatigue, rash and allergic reaction.

Results: The median overall survival was 10.7 months from the start of this treatment.

Correspondence: Dr. V. Georgoulias

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