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Colon Cancer treatment details. Chemotherapy. New York University Cancer Institute, New York, NY, United States



Survival: 13.0 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Leucovorin
Country: United States
   
City/State/Province: New York, NY
   
Hospital: New York University Cancer Institute
   
Journal: Link
   
Date: 12/2007

Description:
Patients: This phase II study involved 55 patients with metastatic colorectal cancer. The mean (average) age was 81 years, ranging from 75-90. Men made up 52.7% of these patients, and women 47.3%.

Treatment: Patients were treated with the chemotherapy drugs uracil-tegafur and leucovorin.

Toxicity: One patient died from cerebrovascular ischemia, which was possibly a result of the study treatment. Grade 4 toxicities were experienced by 4 patients. The grade 4 toxicities were diarrhea, fatigue, hemoglobin levels, bilirubin levels, and constipation.

Results: The median overall survival was 13 months.

Support: Two of the authors of this study received research funds from Bristol-Meyers Squibb Co. This company developed/trademarked leucovorin as Orzel‘.

Correspondence: Dr. Howard S. Hochster

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