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Liver Cancer treatment details. Chemotherapy. California Pacific Medical Center, San Francisco, CA, United States

Survival: 7.4 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Nolvadex
Country: United States
City/State/Province: San Francisco, CA
Hospital: California Pacific Medical Center
Journal: Link
Date: 7/2007

Patients: This phase III study involved 445 patients with unresectable or metastatic hepatocellular carcinoma (liver cancer).

Treatment: The patients were divided into two groups; one half received doxorubicin and the others received nolatrexed. Both of these drugs are chemotherapy.

Toxicity: Grade 3 and 4 adverse events included anemia, thrombocytopenia, neutropenia, leukopenia, fatigue, stomatitis, abdominal pain, anorexia, skin reaction, vomiting and diarrhea. Toxicity was greater in the patients receiving nolatrexed.

Results: The median overall survival for patient s receiving doxorubicin was 32.3 weeks (7.4 months), and for patients receiving nolatrexed, the median overall survival was 22.3 weeks (5.1 months).

Support: Research funds were provided by Eximias Pharmaceutical Corporation, which developed and manufactures nolatrexed. Nolatrexed is also known as NOL and THYMITAQ‚.

Correspondence: Dr. Robert Gish

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