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Brain Cancer treatment details. Immunotherapy. Radiation. Surgery. European Institute of Oncology, Milano, Italy



Survival: 33.5 months
   
Toxicity Grade: 2
   
Treatments: Immunotherapy
Radiation
Surgery
   
Drugs:
Country: Italy
   
City/State/Province: Milano
   
Hospital: European Institute of Oncology
   
Journal: Link
   
Date: 1/2002

Description:
Patients: In this study, there were a total of 37 newly diagnosed glioma patients comprised of 20 glioblastoma multiforme patients and 17 grade 3 glioma patients.

Treatment: Surgery, radiotherapy, three-step radioimmunotherapy (avidin-biotin pretargeting approach to target 90Y-biotin) was administered to 8 of the 20 glioblastoma multiforme patients. In addition, some patients received chemotherapy. The three-step radioimmunotherapy (avidin-biotin pretargeting approach to target 90Y-biotin) involved: administration of biotinylated monoclonal antibody against tenascin which binds to the antigen on the tumor cells surface, administration of avidin, administration of streptavidin which binds to the monoclonal antibody, and the administration of radionuclides.

Toxicity: 42% of the patients developed grade 1-2 hematological toxicity.

Results: The estimate of median survival for the glioblastoma patients who received the full treatment (i.e. including radioimmunotherapy) was 33.5 months.

Correspondence: Dr. G. Paganelli

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