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Brain Cancer treatment details. Chemotherapy. Memorial Sloan-Kettering Cancer Center, New York, New York, United States



Survival: 7.7 months
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
   
Drugs: Temodar
Country: United States
   
City/State/Province: New York, New York
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 1/2002

Description:
Twenty-eight patients had recurrent glioblastoma multiforme and seven patients had various types of recurrent anaplastic glioma. All patients had resection at diagnosis and all but one patient had prior radiotherapy. Twenty-seven patients had received prior chemotherapy.

Treatment: Treatment in this study consisted of the drug temozolomide (temodar).

Toxicity: Grade 3 toxicities occurred in 8 patients (thrombocytopenia, neutropenia and lymphopenia). Other grade 1 and grade 2 toxicities included: hemoglobin, constipation, fatigue, nausea, vomiting, and changes in liver enzymes (i.e. ALP, ALT, AST).

Results: Glioblastoma multiforme patients had a median survival of 7.7 months (measured from the day of study entry).

Support: This study was supported in part by an unrestricted grant from Integrated Therapeutics, Inc. Integrated Therapeutics, Inc. is a subsidiary of Schering-Plough Corporation. Schering-Plough Corporation markets temozolomide.

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