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Lung Cancer treatment details. Chemotherapy. S.G. Moscati Hospital, Avellino, Italy



Survival: 10.0 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: Italy
   
City/State/Province: Avellino
   
Hospital: S.G. Moscati Hospital
   
Journal: Link
   
Date: 10/2007

Description:
Patients: The phase II portion of this study involved 121 patients with advanced non-small-cell lung cancer. The median age was 73, ranging from 67 to 83 years old. The majority of patients were men,.

Treatment: The patients were divided into two treatment groups. Sixty patients were treated with cisplatin and gemcitabine. Sixty-one patients were treated with cisplatin and vinorelbine. These are chemotherapies.

Toxicity: One treatment-related death occurred from febrile neutropenia in the group treated with cisplatin and vinorelbine. Grade 3 and 4 toxicities included leukopenia, neutropenia, anemia, cardiac toxicity, neurological toxicity, and fatigue. The frequency of grade 3 and 4 toxicities was somewhat higher in the group receiving cisplatin and vinorelbine.

Results: The median overall survival was 10 months (43.6 weeks) for patients treated with cisplatin and gemcitabine. For patients receiving cisplatin and vinorelbine, the median overall survival was 7.6 months (33.1 weeks).

Correspondence: Dr. Cesare Gridelli

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