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Prostate Cancer treatment details. Chemotherapy. H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States



Survival: 8.7 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Tampa, FL
   
Hospital: H. Lee Moffitt Cancer Center & Research Institute
   
Journal: Link
   
Date: 8/2007

Description:
Patients: This phase II trial involved 39 men with hormone-refractory, metastatic prostate cancer. All had a prior cytotoxic therapy and their disease progressed. The median age was 73 years, ranging from 42 to 97.

Treatment: All men were given the steroid dexamethasone and the chemotherapy drug thalidomide.

Toxicity: Three instances of grade 4 thrombosis occurred, and there was one report each of grade 4 ureteral obstruction, thrombocytopenia, and leucopenia or neutropenia. Grade 1-2 events were most common, including

Results: The median overall survival was 8.7 months (265 days).

Support: This study was supported by funds from Celgene Corporation, the manufacturer of thalidomide.

Correspondence: Dr. Mayer Fishman

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