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Brain Cancer treatment details. Chemotherapy. Royal Melbourne Hospital, Parkville, Victoria, Australia

Survival: 8.2 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Doxil
Country: Australia
City/State/Province: Parkville, Victoria
Hospital: Royal Melbourne Hospital
Journal: Link
Date: 1/2004

Patients: This Phase II study involved 22 patients with recurrent glioblastoma multiforme. All patients had received radiotherapy, but only 2 had received prior chemotherapy.

Treatment: The treatment consisted of two chemotherapy drugs - temozolomide (temodar) and Caelyx (liposomal doxorubicin - Doxil).

Toxicity: Grade 3-4 toxicities included: thrombocytopenia, neutropenia, rash/dry skin, palmar-plantar changes, nausea/vomiting, reaction to Caelyx, and lethargy.

Results: Median overall survival was 8.2 months.

Correspondence: Mark A. Rosenthal, MD

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