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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. Hospital Universitari del Mar, Barcelona, Spain



Survival: 19.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Spain
   
City/State/Province: Barcelona
   
Hospital: Hospital Universitari del Mar
   
Journal: Link
   
Date: 11/2007

Description:
Patients: This phase II study involved 48 men with advanced hormone-refractory prostate cancer. The median age was 67 years, ranging from 48-78. All had received prior hormone therapy, 54% underwent radiotherapy, and 33% had a prostatectomy.

Treatment: Patients were treated with a combination of chemotherapeutic and biological drugs: estramustine, celecoxib, and docetaxel.

Toxicity: One patient died from a gastric perforation possibly from the use of celecoxib. Grade 3 and 4 toxicities occurring in less than 10% of patients were anemia, neutropenia, diarrhea, stomatitis, anorexia, nausea, vomiting, dyspnea, edema, and onycholisis (finger or toenail abnormality). Grade 3/4 asthenia (weakness) was reported in 15% of patients

Results: The median overall survival was 19.2 months.

Correspondence: Dr. J. Carles

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