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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Norris Comprehensive Cancer Center, Los Angeles, CA, United States



Survival: 16.9 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Los Angeles, CA
   
Hospital: Norris Comprehensive Cancer Center
   
Journal: Link
   
Date: 1/2008

Description:
Patients: This phase II trial involved 70 women with recurrent ovarian cancer. Their median age was 60 years, ranging from 31 to 83. All had received chemotherapy previously with platinum and a taxane.

Treatment: These women were treated with the biological agent bevacizumab and the chemotherapy cyclophosphamide.

Toxicity: Grade 5 toxicity, death related to treatment, occurred in three patients. These deaths were from pulmonary hypotension and an obstruction with a gastrointestinal perforation. Grade 4 lymphopenia occurred in 2 patients, and 1 instance each of grade 4 constipation, gastrointestinal obstruction, low sodium levels, and dyspnea.

Results: The median overall survival was 16.9 months.

Support: Research funding was received from Genentech.

Correspondence: Agustin A. Garcia

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