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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. Immunotherapy. M. D. Anderson Cancer Center, Houston, TX, United States



Survival: 30.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: M. D. Anderson Cancer Center
   
Journal: Link
   
Date: 11/2007

Description:
Patients: This phase II study involved 150 patients with androgen-independent prostate cancer. The majority (100) of the men were between the ages of 50 and 70 years old. These patients had not received a previous treatment with chemotherapy.

Treatment: Patients were treated with one of four drug combinations. These were: Cyclophosphamide, vincristine, and dexamethasone; ketoconazole and doxorubicin with alternating treatments with vinblastine and estramustine; paclitaxel, estramustine, and carboplatin; or paclitaxel, estramustine, and etoposide. If patients did not respond, they were put on one of the other treatment regimens. Symptoms, regression of the tumor, and prostate-specific antigen in patients were used to determine a response to treatment.

Toxicity: Two treatment-related deaths were reported. Thirteen grade 4 toxicites were reported. They were thrombosis/embolism, dyspnea, ureteral obstruction, febrile neutropenia, vomiting, confusion, hypoglycemia, delusions, and musculoskeletal/fracture.

Result: The median overall survival was 22 months. The median survival of patients who had ‘overall success’ as determined by the researchers was 30 months. This group consisted of 44 patients, and 35 of them responded to the first treatment they were given. For the other 106 patients in the study, the median survival time was 19 months.

Correspondence: Dr. Herman P. Pressler

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