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Lung Cancer treatment details. Biologic therapy. Lineberger Comprehensive Cancer Center, Chapel Hill, NC, United States

Survival: 5.4 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Chapel Hill, NC
Hospital: Lineberger Comprehensive Cancer Center
Journal: Link
Date: 2/2008

Patients: This phase II study involved 63 patients with advanced non-small-cell lung cancer. The median age was 60, ranging from 33 to 86 years old. Sixteen percent of the patients had never smoked.

Treatment: Patients were treated with the drug sunitinib. This biological therapy works by affecting the growth of tumors and blood vessels.

Toxicity: Two patients died from treatment-related pulmonary hemorrhage. Grade 4 toxicities included fatigue/asthenia, pain/myalgia, lymphopenia, neutropenia, and thrombocytopenia. These occurred in 5% of patients or less.

Result: The median overall survival was 5.4 months (23.4 weeks).

Support: This study was supported by Pfizer Inc., which developed/markets sunitinib as Sutent®.

Correspondence: Dr. Mark A. Socinski

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