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Rectal Cancer treatment details. Chemotherapy. Istituto Nazionale Tumor, Milan, Italy

Survival: 23.5 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: Italy
City/State/Province: Milan
Hospital: Istituto Nazionale Tumor
Journal: Link
Date: 11/2007

Patients: This phase I/II study involved 38 patients with metastatic colorectal cancer. Their median age was 60, ranging from 35-73 years old. The majority (26) were men. Sixty-six percent of patients had metastatic disease at a single site.

Treatment: Patients were treated with the chemotherapy drugs capecitabine, oxaliplatin, and irinotecan.

Toxicity: The most frequent grade 3-4 toxicities were diarrhea and nausea, which occurred in 24 and 16% of patients, respectively. Other, less common grade 3-4 adverse events included anemia, thrombocytopenia, stomatitis, abnormal enzyme levels, and vomiting. No grade 3 or 4 neutropenia was reported.

Result: The median overall survival time was 23.5 months, ranging from 7.6 to over 38.2 months.

Correspondence: Dr E. Bajetta

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