Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Brain Cancer treatment details. Chemotherapy. Radiation. Mayo Clinic, Rochester, MN, United States



Survival: 12.0 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 8/2006

Description:
Patients: This phase III study involved 401 patients with newly diagnosed glioblastoma multiforme. The median age was 56 years, and the majority (over 60%) were men.

Treatment: The patients were divided into four different treatment Ďarmsí. Arm A received the chemotherapy drug carmustine and standard radiation therapy; Arm B received carmustine and accelerated radiation therapy; Arm C received carmustine, cisplatin, and standard radiation therapy; Arm D received carmustine, cisplatin, and accelerated radiation therapy.

Toxicity: The most common toxicities were neutropenia, thrombocytopenia, nausea, vomiting, lethargy, headache, neurosensory changes, hearing loss, alopecia, anorexia, and skin reactions. One death due to neurocortical toxicity occurred. Four patients died from infections related to treatment.

Results: The median survival time for patients that received carmustine and standard radiation therapy (Arm A) was 10.4 months. For patients that received carmustine and accelerated radiation therapy (Arm B), the median survival time was 10.1 months. Patients that received carmustine, cisplatin, and standard radiation therapy (Arm C) had a median survival time of 12.0 months, and those in Arm D (received carmustine, cisplatin, and accelerated radiation therapy) had a median survival time of 11.6 months.

Correspondence: Jan Buckner, M.D.

E-mail to a Friend Email Physician More Information