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Brain Cancer treatment details. Chemotherapy. M.D. Anderson Cancer Center, University of Texas, Houston, Texas, United States



Survival: 8.8 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: M.D. Anderson Cancer Center, University of Texas
   
Journal: Link
   
Date: 1/2002

Description:
Patients: This Phase I/II study involved 24 patients with recurrent or progressive malignant gliomas. Sixteen patients had glioblastoma multiforme, six patients had anaplastic astrocytoma, 1 patient had an anaplastic oligodendroglioma, and one patient had a mixed glioma. All patients had prior surgery and 18 patients had prior chemotherapy. All patients had prior radiotherapy.

Treatment: The treatment consisted of a new drug, CI-980 (a mitotic inhibitor).

Toxicity: Toxicities included grade 4 or less hematologic toxicity, hepatic/GI, hyperglycemia, stomatitis (grade 3), and neurologic toxicity .

Results: There were no responses and median survival for all patients was 38 weeks (8.8 months).

Correspondence: W.K. Alfred Yung, MD

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