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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Mount Sinai Cancer Center, Miami Beach, FL, United States



Survival: 14.9 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Miami Beach, FL
   
Hospital: Mount Sinai Cancer Center
   
Journal: Link
   
Date: 2/2008

Description:
Patients: This phase II trial involved 103 patients with advanced non-small-cell lung cancer.

Treatment: Patients were treated with either erlotinib (a biological therapy) or paclitaxel and carboplatin (chemotherapy drugs).

Toxicity: Three patients died from causes related to treatment, one receiving erlotinib and two receiving chemotherapy. One patient died from pulmonary infiltrates and interstitial lung disease, and the other two died from febrile neutropenia. Grade 4 pulmonary embolism was reported, as were grade 3 diarrhea, anemia, thrombocytopenia, and elevated liver enzymes.

Results: The median overall survival was 6.6 months for patients treated with erlotinib and 9.5 months for those treated with the chemotherapy drugs (paclitaxel and carboplatin). Some patients treated with chemotherapy switched to erlotinib, and the median overall survival of these twenty-nine patients was 14.9 months.

Support: This study was supported by OSI Pharmaceuticals, Inc. This company markets erlotinib as TarcevaŽ (through a partnership with Genentech, Inc.in the U.S. and with Roche in other countries).

Correspondence: Dr. Rogerio Lilenbaum

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