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Liver Cancer treatment details. Radiation. Princess Margaret Hospital, Toronto, Canada

Survival: 13.4 months
Toxicity Grade: 3
Treatments: Radiation
Country: Canada
City/State/Province: Toronto
Hospital: Princess Margaret Hospital
Journal: Link
Date: 2/2008

Patients: This phase I study involved 31 patients with hepatocellular carcinoma and 10 patients with intrahepatic cholangiocarcinoma. The median age of patients with liver cancer was 62, ranging from 41 to 85 years old. There were 31 men and 10 women in this study.

Treatment: Patients were treated with stereotactic body radiotherapy. This kind of radiation is given at a higher dose, but less often then traditional radiotherapy.

Toxicity: Two patients died, over one year after receiving this treatment, one from a gastrointestinal bleed and the other from a bowel obstruction and progressive disease. These deaths were attributed to disease, and possibly related to the treatment. Grade 3 elevated liver enzymes, nausea, thrombocytopenia, and lethargy were reported. The most common grade 3 toxicity was an increase in liver enzymes, which was reported in eight patients with hepatocellular carcinoma and two patients with intrahepatic cholangiocarcinoma.

Results: The median overall survival of all patients was 13.4 months. The median survival time for patients with hepatocellular carcinoma was 11.7 months, and for those with intrahepatic cholangiocarcinoma the median survival time was 15 months.

Support: This research was supported by funds from Elekta Oncology Systems, a company which makes and markets products for radiation therapy and other treatments for cancer.

Correspondence: Dr. Laura Dawson

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