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Prostate Cancer treatment details. Chemotherapy. St Bartholomew's Hospital, London, United Kingdom



Survival: 7.7 months
   
Toxicity Grade:
   
Treatments: Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: London
   
Hospital: St Bartholomew's Hospital
   
Journal: Link
   
Date: 1/2008

Description:
Patients: This phase II study involved 43 men with androgen-independent prostate cancer. They ranged in age from 50 to 86 years old. The median age was 72.

Treatment: After undergoing initial chemotherapy and endocrine therapy, patients were given another endocrine-targeted therapy. Specifically, patients were treated with the chemotherapy drugs chlorambucil, lomustine, and etoposide. When their disease progressed, they were treated with endocrine therapy, the hormones bicalutamide and GnRH analogue. After this treatment ‘failed’ they were treated with the hormone diethylstilbestrol and the anti-inflammatory drug dexamethasone.

Toxicity: No information reported

Results: The median overall survival was 7.7 months, from the time of starting the second round of endocrine therapy.

Correspondence: Dr. Jonathan Shamash

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