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Lung Cancer treatment details. Immunotherapy. Hospital Hermanos Ameijeiras, Ciudad Habana, Cuba



Survival: 6.4 months
   
Toxicity Grade: 2
   
Treatments: Immunotherapy
   
Drugs:
Country: Cuba
   
City/State/Province: Ciudad Habana
   
Hospital: Hospital Hermanos Ameijeiras
   
Journal: Link
   
Date: 3/2008

Description:
Patients: This phase II study involved 80 patients with advanced non-small-cell lung cancer. The median age was 55.5, ranging from 30 to 78 years of age. The majority (74%) were men. All had previously received a platinum-based chemotherapy, and almost half received a radiation treatment.

Treatment: Patients were either treated with a vaccine or received best supportive care. This vaccine is designed to cause patients immune system to attack cells that express the epidermal growth factor receptor.

Toxicity: No grade 3 or 4 toxicities were reported. Grade 1 and 2 toxicities included fever, chills, nausea, vomiting, tremor, headache, arthralgia, asthenia, pain at the injection site, and acneiform rash.

Results: The median overall survival of vaccinated patients was 6.47 months and 5.33 months for the control group. Among the vaccinated patients, those with a good immune response to the vaccine had a median overall survival of 11.7 months. Those that did not have a good immune response to the vaccine had a median overall survival of 3.6 months.

Correspondence: Dr. Elia Neninger Vinageras

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