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Brain Cancer treatment details. Chemotherapy. Radiation. Johns Hopkins Oncology Center, Baltimore, Maryland, United States

Survival: 11.6 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: United States
City/State/Province: Baltimore, Maryland
Hospital: Johns Hopkins Oncology Center
Journal: Link
Date: 1/2004

Patients: This Phase II study involved 55 patients with newly diagnosed glioblastoma multiforme.

Treatment: Treatment consisted of the drug suramin and radiotherapy.

Toxicity: One patient died of central nervous system ischemia. Another patient died of progressive cerebral edema during radiation. Both deaths are “possibly related to suramin.” Grade 4 toxicities included fatigue, cerebral edema, neuropathy, pancreatitis, pulmonary, renal, central nervous system hemorrhage, leucopenia, and electrolyte imbalance.

Results: Median survival was 11.6 months.

Correspondence: John Lattera, MD

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