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Liver Cancer treatment details. Biologic therapy. Chemotherapy. Hopital Europeen Georges Pompidou, Paris, France

Survival: 9.5 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: France
City/State/Province: Paris
Hospital: Hopital Europeen Georges Pompidou
Journal: Link
Date: 6/2008

Patients: This phase II study involved 45 patients with advanced-stage progressive hepatocellular carcinoma. They ranged in age from 22 to 76 years old; the median age was 63 years of age.

Treatment: Patients were treated with the chemotherapy drugs gemcitabine and oxaliplatin and the biological therapy cetuximab (a monoclonal antibody).

Toxicities: Grade 3 and 4 toxicities included skin rash, neurotoxicity, nausea/vomiting, thrombocytopenia, neutropenia and anemia. Grade 2 allergic reactions were reported in 2 patients.

Results: The median overall survival was 9.5 months.

Support: This study was supported by Merck Lipha Sante. Merck markets cetuximab as Erbitux®.

Correspondence: Dr. Julien Taieb

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