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Brain Cancer treatment details. Chemotherapy. John Hopkins University School of Medicine, Baltimore, MD, United States

Survival: 7.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United States
City/State/Province: Baltimore, MD
Hospital: John Hopkins University School of Medicine
Journal: Link
Date: 2/2008

Patients: This phase II study involved 76 patients, 51 with glioblastoma multiforme and 19 with anaplastic astrocytoma.

Treatment: Patients were treated with the chemotherapy drugs cisplatin, hydroxyurea, and cytosine arabinoside (Ara-C).

Toxicities: Two patients died of sepsis. Grade 4 hematological toxicities were reported in 20 patients, including thrombocytopenia and neutropenia. Other grade 3 and 4 toxicites were creatinine increase, infection, nausea, inner ear hearing loss, and fatigue.

Results: The median overall survival was 7 months for patients with anaplastic astrocytoma and 5 months for those with glioblastoma multiforme.

Correspondence: Dr. Lode J. Swinnen

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