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Brain Cancer treatment details. Chemotherapy. MD Anderson Cancer Center, Dallas, TX, United States



Survival: 8.3 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Dallas, TX
   
Hospital: MD Anderson Cancer Center
   
Journal: Link
   
Date: 4/2008

Description:
Patients: This phase II study involved 32 patients with recurrent glioblastoma multiforme. The median age was 46.5 years, ranging from 21 to 65. The majority, 75%, were men.

Treatment: Patients were treated with the chemotherapy drugs irinotecan and thalidomide.

Toxicities: Two patients died from causes possibly related to treatment. Grade 4 neutropenia, lymphopenia, seizure, venous thromboembolism, and lymphopenia was reported. Grade 3 toxicities included leukopenia/neutropenia, diarrhea with abdominal cramping/pain.

Results: The median overall survival was 36 weeks (8.3 months) from the time the patients entered the study.

Support: This study was supported by research grants from Pfizer Pharmaceuticals and Celgene Corporation. Thalidomide is marketed by Celgene as Thalomid.

Correspondence: Dr. Vinay Puduvalli

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